Manager, Finance

X4 Pharmaceuticals

X4 Pharmaceuticals

Accounting & Finance
Boston, MA, USA
Posted on Jan 15, 2026

Do you have the passion and commitment to join a team whose mission is to develop treatments that have a clear and profound impact on people with rare diseases? Does it excite you to be a part of a company developing potential new treatments that could dramatically improve the lives of people with limited to no treatment options? Named one of the Top Places to Work by The Boston Globe, X4 is an exceptional place, focused on open communication and collaboration and dedicated to each other, our partners, and the medical community.


With the April 2024 U.S. approval of our first drug XOLREMDI™ (mavorixafor), we have made great progress in advancing our patient-centric mission and in evolving the company into a fully integrated pharmaceutical company. But there is so much left to do! We are continuing to explore global opportunities for mavorixafor in its first indication, while also advancing mavorixafor for people with chronic neutropenia through an ongoing pivotal, global Phase 3 clinical trial.

We recognize that developing innovative, new medicines is challenging, but we embrace this challenge to truly make progress for patients each day. If you feel you would be a good fit for X4, we invite you to share with us your aspirations and career goals.

At X4 you will find…

  • A team that values grit and passion of innovative science.
    • The opportunity to leverage your knowledge of Finance to support our innovative science and allow you to have a major impact on our mission to support our patients.
  • A collegial environment with a team-based approach, where our mission drives our values, behaviors, and creativity.

Your Responsibilities:

  • Form and maintain strong business partnerships and become the key resource to stakeholders within other departments
  • Review and approval of purchase orders, ensuring all finance related matters are addressed and the efficiency of the overall process
  • Completion of monthly close accurately and timely, including creation of journal entries, account reconciliations and variance analysis commentary to be presented at the monthly close meetings
  • Ensure compliance with SOX requirements and accounting policy and procedures
  • Maintain control of key areas of balance sheet and support external audit
  • Monthly variance analysis to drive accountability and influence corrective action recommendations as needed
  • Establishing and managing our budgets and financial forecasts, working with key business stakeholders and external vendors (e.g. CROs)
  • Utilize appropriate analytics and benchmarks to produce an accurate, quality study model that is updated regularly, while maintaining constant fiscal vigilance on trial spend and trends
  • Other ad-hoc requests or projects as needed

What You Will Bring:

Required Skills

  • Bachelor's Degree in Finance, Accounting or equivalent
  • Minimum of 5+ years of working finance experience within financial planning or accounting
  • Knowledge and understanding of U.S. GAAP, and SOX compliance requirements
  • Strong financial acumen with a value creation mindset
  • Strong oral and written communications inclusive of presentation abilities
  • Demonstrated ability to influence and build strong working relationships with business partners
  • High sense of urgency with the ability to meet tight deadlines while maintaining flexibility to adapt to changing priorities
  • Preferred Skills
  • Life sciences industry experience, particularly supporting research and development/clinical trials
  • MBA or CPA a plus

This position is based in Boston, MA, and offers a flexible hybrid work model with a minimum of 2 days/week in the office.

We encourage you to learn more about X4 Pharmaceuticals. Click on the links below!

About Us

Pipeline

X4 Pharmaceuticals is an Equal Opportunity, and Affirmative Action Employer committed to a culturally diverse workforce. All qualified candidates will receive consideration without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender identity or expression, sexual orientation, disability, veteran status, violence victim status or any other characteristic protected by law.