The Opportunity:

We are looking for a self-motivated person with broad knowledge and hands-on experience with mass spectrometry and other characterization techniques. We are applying state of the art technologies towards the discovery, characterization, and optimization of small molecule therapeutics for targets presenting high unmet medical needs.

You will play a central role in the development and implementation of novel mass spectrometry-based methods to help characterize drug targets and discover potential small molecule drug candidates. Further, you will plan, develop, optimize and execute experiments for the binding affinity, physicochemical analysis and structural characterization of these drugs. This is a unique opportunity that will expose you to a wide range of activities and you will be expected to contribute experimentally, as well as intellectually, to the progress of our drug discovery efforts and development of our growing portfolio.

Your Role:

• You will be pivotal in Relay’s mass spectrometry-based characterization efforts

• You will be involved in the development and application of mass spec-based compound screening technologies, such as affinity selection MS

• You will develop and use methods such as peptide mapping, HDX-MS, ion-mobility, and native MS for the characterization of drug targets and their interactions to support the drug discovery efforts of various projects

• You should expect that analysis, interpretation, documentation, presentation and discussion with project teams around the impact of your data on the general drug discovery strategy will be part of your day

• You will maintain awareness of the current and relevant scientific literature, particularly in areas of mass spectrometry, and actively apply new concepts as appropriate

• We will depend on you to assess, adopt, and implement current and new methodologies and experimental techniques complementing mass spectrometry that will improve and enable drug discovery

• Your voice is important. You will be a key contributor and collaborator on multidisciplinary teams where your opinions will be highly valued

Your Background:

• You earned a PhD in Chemistry, Biophysics, or a related discipline

• You have spent at least 4 years gaining relevant industry and/or postdoctoral experience

• You have hands-on experience with biomolecule mass spectrometry, developing and using state-of-the-art methods to characterize drug targets, as well as experience in small-molecule characterization and binding to drug targets through affinity-based MS and other methods. Experience in HDX-MS and other protein characterization methods is a plus.

• You have worked on mass spectrometers from different vendors

• You're an articulate, open communicator with the ability to analyze, interpret and present data in a clear manner

• You are scientifically curious and have demonstrated a willingness to strategically impact the drug discovery process of various projects

• You have a track record of scientific excellence as reflected by high impact, peer reviewed publications and/or patents

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