<div><strong>Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems.</strong><span style="color: #262626;"> Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works</span><span style="color: #262626;">&nbsp;across this full stack to pursue programs both internally and with leading pharma companies.</span></div> <p><strong>Position</strong></p> <p>We are seeking an experienced and highly organized <strong>In Vivo Study Coordinator</strong> to own the end-to-end planning, coordination, and execution of our preclinical in vivo pharmacology programs. This is a senior, hands-on role at the intersection of scientific rigor and operational excellence — you will be the single point of accountability for study lifecycle management across multiple parallel programs, from initial study design through execution, collection, and delivery.</p> <p>The ideal candidate brings deep in vivo pharmacology expertise, strong cross-functional coordination instincts, and the ability to operate independently in a fast-moving, early-stage environment. You are as comfortable building a detailed study timeline as you are troubleshooting a dosing day in real time — and you know when to push back on unrealistic timelines and when to find creative solutions.</p> <p><strong>Responsibilities</strong></p> <ul> <li>Own end-to-end study coordination across multiple concurrent in vivo programs — from animal ordering and acclimation through dosing, bleeding, necropsy, tissue collection, and downstream handoff</li> <li>Develop and maintain detailed study plans, timelines, and execution schedules — including who does what, when, and how, with clear accountability at every step</li> <li>Serve as the primary point of contact between scientists, VIVO team members, vivarium staff, and external CROs — ensuring alignment on study design, timelines, and deliverables</li> <li>Contribute to study design in collaboration with program leads — including dose selection, group sizes, timepoints, route of administration, and endpoint strategy</li> <li>Perform and oversee hands-on in vivo procedures including dosing (IV, SC, IP, PO), bleeds, perfusion, necropsy, and tissue collection as needed</li> <li>Write, review, and refine study protocols and SOPs; contribute to protocol amendments as studies evolve</li> <li>Track and manage animal orders, reagent inventory, and study materials to ensure readiness ahead of each experiment</li> <li>Identify bottlenecks and resource conflicts across the study portfolio and proactively surface solutions</li> <li>Mentor and train junior VIVO team members on in vivo techniques and study execution best practices</li> <li>Maintain accurate, organized records and data entry in Benchling and other platforms</li> <li>Coordinate with external CROs and vendors on outsourced study components — review SOWs, monitor timelines, and ensure data quality</li> </ul> <p><strong>Required Qualifications</strong></p> <ul> <li>Bachelor's or Master's degree in Biology, Pharmacology, Biomedical Science, or related field</li> <li>5+ years of hands-on in vivo pharmacology experience in a biotech, pharma, or CRO environment</li> <li>Demonstrated experience as a study director, study coordinator, or study lead — owning studies end-to-end with accountability for timelines and deliverables</li> <li>Deep proficiency with in vivo techniques: IV, SC, IP, and PO dosing; submandibular and cardiac bleeds; necropsy; tissue collection and processing across a broad panel</li> <li>Experience coordinating multiple concurrent studies across different programs and timelines</li> <li>Strong organizational skills and attention to detail — you do not let things slip</li> <li>Excellent cross-functional communication — comfortable working with scientists, RAs, vivarium staff, and leadership simultaneously</li> <li>Self-motivated and capable of operating independently with minimal supervision</li> <li>A genuine passion for science and for building something impactful</li> </ul> <p><strong>Preferred Qualifications</strong></p> <ul> <li>Experience with humanized or disease mouse models</li> <li>Familiarity with NHP study coordination and CRO management</li> <li>Experience with downstream bioanalytical assays — ELISA, MSD, qPCR, western blot, flow cytometry, IHC, IF</li> <li>Familiarity with histology, tissue sectioning, and confocal imaging workflows</li> <li>Experience with Benchling or similar LIMS platforms</li> <li>Exposure to protein therapeutics and other modalities</li> <li>Experience writing detailed study plans, SOPs, and IACUC protocol amendments</li> <li>Comfortable with data analysis tools including GraphPad Prism and Microsoft Office</li> </ul> <p><strong>Base Salary Range: </strong>$106,000 - $123,000</p> <p>This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.</p> <p>This role is eligible for:</p> <ul> <li>Annual performance-based target bonus</li> <li>Stock options</li> <li>Comprehensive medical, dental, and vision coverage</li> <li>401(k) plan</li> <li>Flexible paid time off and holidays</li> <li>Perks including on-site gym, onsite lunch, and commuter support</li> </ul> <p>Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.</p> <p><strong>If you’re excited to build a platform that combines DNA and protein multiplexing technologies, please reach out to careers@manifold.bio.</strong></p><div class="content-conclusion"><p><em style="color: rgb(34, 34, 34); font-family: Arial, Helvetica, sans-serif; font-weight: 400; letter-spacing: normal; text-align: start; white-space: normal; word-spacing: 0px; text-decoration: none;"><em><span style="font-weight: 400;">We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.</span></em></em></p></div>